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New mechanism in regulating selective autophagy

Autophagy is crucial for maintaining cellular homeostasis. It can be divided into non-selective autophagy and selective autophagy, both of w...

New aggrephagy receptor for clearance of solid protein aggregate...

Aggrephagy, the degradation of protein aggregates via autophagy, is an important biological process to clear intracellular toxic protein agg...

Structures of Tetrahymena ’s respiratory chain reveal the diver...

Oxidative phosphorylation is the major cellular process utilized by most free-living eukaryotes to gain energy, in the form of ATP, from cat...

β-NMN delays myelin ageing and enhances myelin repair in the ag...

Myelin is a multiple-layered structure formed by oligodendrocytes. The ensheathment of axons by myelin plays an important role in both funct...

Gut microbiota modulates the host epitranscriptome modification ...

Colorectal cancer is one of the common malignant tumors, which seriously endangers the health of the nation. Despite the development of trea...

Scientists uncover a new tumor cells-fibroblasts juxtacrine sign...

The interaction between tumor cells and cells in the microenvironment is crucial for tumor metastasis. At present, there is an in-depth unde...

Ratiometrically designed nanoprodrug for triple-negative breast ...

Effective combination therapies are urgently needed to treat triple-negative breast cancer (TNBC), which is insensitive to the existing trea...

ZJU scientists identify ultrathin osteochondral interface tissue...

The knee joint is the largest and most complex weight-bearing joint in the human body that enables us to stand and carry out our daily tasks...

Lactylation/METTL3/m6A axis promotes the immunosuppression of TI...

The crosstalk between immune cells and tumor cells within tumor microenvironment crucially determines the fate of tumor progression and meta...

Extracellular vesicles derived from NELL1-modified mesenchymal s...

EVs are nanoparticles (30–200 nm) secreted by various cell types, and the lipid bilayer of EVs can retain their bioactivity for a long time ...

A plant-based diet with better quality might lower mortality ris...

A plant-based dietary pattern is usually defined as a diet rich in plant-based foods and low level of animal-based foods, and has received a...

New mechanism in preventing CAR-T cell exhaustion

In recent years, chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable success in treating patients with relapsed or refr...

ZJU scientists develop “musical dish” to induce osteogenic dif...

Stretch, as a form of mechanical force, plays a crucial role in regulating cell behaviors, preventing injuries and repairing tissues such as...

ZJU scientists elucidate novel molecular mechanism of MYBPC3-rel...

Hypertrophic cardiomyopathy (HCM), characterized by left ventricular hypertrophy and fibrosis, is the most common monogenic cardiovascular d...

Therapeutic potential of opioid agonists in human leukemia

Leukemia, the blood cancer, is a group of hematopoietic malignancies. Many types of leukemia are associated with poor outcome. Unfortunately...