The expression of histamine receptor 1-4 (H1- 4R) and histamine methyltransferase was determined in the histamine projection areas which are strongly involved in Parkinson’s disease (PD), i.e. the substantia nigra and striatum, with quantitative polymerase chain reaction and immunocytochemistry. In addition, the relationship between the expression of these molecules and PD pathologies and disease course were analyzed. We found for the first time brain-area-specific changes of neuronal histaminergic system in PD. This may provide scientific evidence for novel therapeutic strategies. The paper was published in Neurobiology of Aging.
Acute kidney injury (AKI) signifies a sudden and prolonged decline in kidney function characterized by tubular cell death and interstitial inflammation. Small nucleolar RNAs (snoRNAs) are conserved no...
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric and 25% of adult cases of acute lymphoblastic leukemia (ALL). Even though allogeneic hematopoietic stem cell transplantation (...
Some gut bacteria can collaborate to promote T-cell action against tumours in mice, raising hopes for treatments.A new study led by Zhejiang University researchers has identified ways by which some mi...
