Zhejiang University School of Medicine Discover

Prof. Hongwei Ouyang's Group Published a Paper to Reveal the Beneficial Effect of a Bi-Lineage Condu

2015-09-30   |  

Since cartilage and bone tissues have different lineage-specific biological properties, it is challenging to utilize a single type of scaffold to biologically fulfill the both requirements for regenerating these two lineages in osteochondral defects. To overcome this challenge, a research team led by professor Hongwei Ouyang developed a lithium-containing mesoporous bioactive glass (Li-MBG) scaffold. Based on imaging studies on animal model, this Li-MBG scaffold showed beneficial effects on regeneration of both cartilage and subchondral bone, and these effects were related to enhanced osteogenic differentiation of bone mesenchymal stem cells as well as protection of cartilage tissues from the inflammatory osteoarthritis environment through activation of autophagy. These findings suggest that Li-MBG is a bi-lineage conducive scaffold for osteochondral defect regeneration.

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